First, the primary factor(The cause of primary NS is not clear, but with the following factors)
(A) genetic factorsChildren with nephrotic syndrome in the prevalence of compatriots and twins accounted for about 2% -6%. It may increase the sensitivity of the pathogenesis of minor lesions.
(B) - allergic body qualityIto studied the HLA antigens of various kidney diseases in children, indicating that NS had 35.3% of allergic factors and 6.7% in the control group, which was related to HLA-B40. There have been reports of NS metamorphosis history accounted for 40%.
(C) immune mechanisms
NS is associated with humoral immunity, immune complex formation, and cellular immunity. Elzouki (Ai Luke 1984) survey report, Arabian children with primary nephrotic syndromeThe incidence rate of 11.6 a few. Million children.
The higher incidence of the disease may be related to climate, geography, the type of child infection, the genetic characteristics of the Arab population, many factors may affect the immune pathogenesis of kidney disease.Second, secondary factors
(A) infection
1, bacterial infection: streptococcal infection after nephritis, bacterial endocarditis, shunt nephritis, syphilis, leprosy, chronic pyelonephritis with reflux nephritis.
2. Viral infection; hepatitis B, infectious mononucleosis, Cy-tomegalovirus, post-vaccine nephritis.
3. Parasitic infections: three malaria, Toxoplasnosis, Helminthic (sehistoso-miasis).
(B) drugs
Poisoning, allergic, organic or inorganic mercury, organic gold, bismuth, silver, penicillamine, heroin, probenecid, trimethophenone, Captopril, bee sting, snake venom, pollers, antitoxin or vaccine allergy.
(C) new creatures
Solid tumor (Careinoma or sarcoma): lung, colon, stomach, breast, kidney, thyroid, ovarian and other tumors, wilm's tumor.
Lymphoma and leukemia, Hodgkin's disease, non-Hodgkin's lymphoma, chronic lymphocytic leukemia, multiple myeloma.
(D) Department of 6L disease
Systemic lupus erythematosus, mixed connective tissue disease, Sjogren's syndrome, rheumatoid arthritis, allergic purpura, necrotizing vasculitis, polyarteritis, cryoglobulinemia, amyloidosis, sarcoidosis.
E) metabolic diseases
Diabetes, mucus edema.
(F) hereditary disease
Alport, Syndrome, Fabry's Disease, Nail-patella Syndrome, Congenital Nephrotic Syndrome (Finnish), familial nephrotic syndrome, sickle red blood cell anemia.
If you still have any doubts, you can feel to contact
me by E-mail :chinakidneyhospital@gmail.com,or WhatsApp : 008615132830921.
our
doctor will reply you with professional
suggestion.