According to hospital experts, nephrotic syndrome, the reasons for the high degree of edema is mainly affected by two aspects:
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(1) decreased plasma colloid osmotic pressure: the exchange of blood vessels inside and outside the body by its osmotic pressure on both sides of the regulation. Osmotic pressure, including osmotic pressure and colloid osmotic pressure, the former from the crystal material (mainly electrolyte), because it is free to pass through the capillary wall, so the internal and external blood vessels within the exchange of little effect; the latter mainly from the protein (which is mainly Albumin), because it is not free through the capillary wall, which is the main factor in the exchange of blood vessels inside and outside the main factors.
Nephrotic syndrome, due to a large number of plasma protein loss from the urine, causing hypoproteinemia, resulting in decreased plasma colloid osmotic pressure, when the normal 3.3 ~ 4kPa down to 0.8 ~ 1.1kPa, the blood vessels Water to hypertonic interstitial fluid movement, and edema occurred.
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(2) reduced effective blood volume: the removal of plasma water to reduce the effective blood volume, which led to the following changes in the body: through the capacity of the sensor to increase antidiuretic hormone (ADH), renal tubular reabsorption of water increased; Su - angiotensin - aldosterone system, resulting in secondary aldosteronism, renal tubular reabsorption of sodium increased; inhibition of natriuretic factor production, the kidney to reduce sodium. So the body of water, sodium retention, further aggravated edema. The above two factors together cause a high degree of edema of nephrotic syndrome.
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