Purpura nephritis

Purpura nephritis, also known as allergic purpura nephritis, is allergic purpura with renal damage when the performance. If not properly, actively and effectively treated, purpura nephritis will develop to uremia. For patients with purpura nephritis, a comprehensive understanding of the disease on their recovery of the disease have some help.Etiology

1. infection: including bacteria, viruses and parasites or schistosomiasis infection. About 1/3 of the patients before the onset of infection, the most common respiratory tract infection. There are reports of β-hemolytic streptococcus, Mycobacterium tuberculosis, pneumococcus, Staphylococcus aureus, varicella virus, measles virus, influenza virus, human papilloma virus, Salmonella, HIV, Chlamydia pneumoniae and schistosomiasis. Causes of the pathogenesis of purpura nephritis?

2. Drugs: antibiotics (penicillin, erythromycin, tetracycline, etc.), sulfonamides, isoniazid, salicylic acid, quinine, carbamazepine, thiazide diuretics, phenacetin, thiopental, Kinase, lilapril, retinopril, barbiturate, iodide, aspirin, vaccine (measles vaccine, epidemic cerebrospinal meningitis vaccine, etc.), tuberculin test.

3. Food: fish, shrimp, crab, eggs, clams, milk and other heterosexual protein more common; white wine, nuts, green beans, tomatoes, strawberries, wheat and chocolate are also reported

4. Other pollen allergies, insect bites and cold stimuli.symptom

Purpura nephritis in addition to causing kidney damage, but also cause multiple parts of the discomfort.

1. Rash: rash is often the starting and the main clinical manifestations of the performance occurred in the distal limbs, buttocks and lower abdomen, multi-symmetrical distribution, slightly higher than the skin surface, may have itching, 1 to 2 weeks after the gradual regression , Often can be in batches. From purpura to kidney damage interval of less than 2 weeks.

2. Joint pain: joint pain is a common symptom of purpuric nephritis, the performance characteristics of multiple and non-migratory, and the symptoms occur in the nude joint pain.

3. Abdominal discomfort: mainly for abdominal pain, abdominal discomfort and diarrhea. Common parts for the umbilical and lower abdomen. Abdominal pain can sometimes be expressed as paroxysmal colic.

In addition to these, lymph nodes, hepatosplenomegaly and nervous system involvement such as headache, convulsions and behavioral abnormalities.

4. Urine abnormalities: urinary abnormalities in purpura nephritis mainly refers to the hematuria and proteinuria. These two symptoms usually appear within one month after skin purpura, some or colleagues can see skin purpura, abdominal pain, and some are just asymptomatic urine abnormalities.

PathogenesisThe pathogenesis of purpuric nephritis and the body's immune system is closely linked. It is caused by allergic purpura. Allergic purpura is a systemic complex vasculitis mediated by immune complexes. Purpura nephritis is also immune to complex nephritis. Its pathogenesis is mainly through humoral immunity, but also involves cellular immunity, some cytokines and inflammatory mediators, coagulation Mechanisms are involved in the disease pathogenesis.

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